After Pherill’s resignation in 1929 he was replaced by Reverend R.W. Lane, with Burford being his first parish. Like the vast majority of churches, Holy Trinity went through some very lean times during the Great Depression, with Lane offering to forgo four hundred dollars of his stipend so that the work of the Church could continue. A furnace and central heating system were installed during Lane’s tenure as well as new main doors courtesy of Grace Church, Toronto. Lane was transferred to Norwich in 1934 and replaced by Reverend C.F. Johnson who held the position until 1938.

In January 1939 Reverend George Bulger arrived at Holy Trinity and oversaw the sale of Holy Trinity’s parish hall. That same year St. John’s Church in Cathcart closed and the church was offered to Holy Trinity to serve as a new parish hall. Moving the building from Cathcart to Burford encountered a number of difficulties, including the church having to be raised eight feet in order to cross a bridge. 1939 also saw up to that time the largest congregation (over 300 people) ever to attend Holy Trinity when on May 21 the Right Reverend G.A. Wells confirmed sixteen candidates. In 1941 Bulger took a leave of absence and joined the Armed Forces as a Chaplain, a position he held until the end of the Second World War. Reverend T.H. Inns arrived at Holy Trinity in 1941 and during his incumbency both the Church and parish hall were renovated. The parish hall was also used as a Red Cross Centre where supplies were stored and shipped during the Second World War.

Inns left in 1947 and was replaced by Reverend Albert Reginald Marshall. A number of memorials were added to the Church during Marshall’s tenure, including a pipe organ in memory of Holy Trinity parishioners who had served in the World Wars. In 1948 the Church interior was redecorated to celebrate the one hundred thirteenth anniversary of Anglican worship in the area, the ninety-eighth anniversary of the opening of Holy Trinity, and the one hundred fifth anniversary of the laying of the Church cornerstone. In 1949 Albert Marshall left Holy Trinity for the Diocese of Michigan and was replaced by George Pierce. Holy Trinity’s one hundredth anniversary was celebrated on August 10, 1952 and construction of a new rectory was completed in 1955. In 1956 George Pierce left Holy Trinity and was replaced by Reverend James Waring. Holy Trinity underwent significant renovations during Waring’s tenure, including a new furnace, carpets, and washroom facilities. The Women’s Auxiliary celebrated its seventieth anniversary on October 10, 1957.